The disgruntled deputy governor lamented that the county, in the guise of undertaking renovations, had his office partly demolished.
Dr Issa claimed that he is hardly invited to Cabinet meetings for allegedly questioning the infrequency of the forums.
Governor Wycliffe Oparanya last week reshuffled his Cabinet and stripped his deputy, Prof Philip Kutima, of the Agriculture docket.
The governors of Isiolo and Kakamega have fallen out with their deputies, leading to supremacy battles in the regions.
In Isiolo, Deputy Governor Abdi Issa, whose rift with Governor Mohamed Kuti started in 2018 after he was stripped of his powers as the Health executive, said his boss had refused to respond to several concerns he had previously raised with him, including not being invited to Cabinet meetings and withdrawal of his office budget.
